2. Doctor Octopus

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For years, the Green Goblin was considered Spider-Man’s greatest villain, but that title arguably now belongs to Doctor Octopus. Why? Well, he recently managed to kill Peter Parker by switching their minds in a Freaky Friday type of scenario which saw the heroic wallcrawler die in the body of the ailing Otto Octavius, resulting in the villain becoming the “Superior” Spider-Man.

It’s been controversial to say the least, and while it’s not necessarily a storyline which should be adapted for the big screen, it has created a renewed interest in the villain. The character may have been expertly played by Alfred Molina in the brilliant Spider-Man 2, but that was quite an original take on him, and Goddard thereby has the chance to pick and choose from both the classic comics and Ultimate Universe to create a very different – and must-see – take on Doc Ock.